Lactated Ringer's solution was superior to NSS in SIRS reduction in acute pancreatitis only in the first 24 h. The median length of hospital stay was not significantly different in the two groups (5.5 days in NSS, 6 days in LRS, P = 0.915). Local complications were 29.2% in NSS and 21.7% in LRS (P = 0.74). CRP, ESR and procalcitonin increased at 24 h and 48 h after admission with no difference between the two groups. Mortality was not different between NSS and LRS (4.2% in NSS, 0% in LRS, P = 1.00). However, SIRS reduction at 48 h was not different between groups (33.4% in NSS, 26.1% in LRS, P = 0.88). There was significant reduction in SIRS after 24 h among subjects who resuscitated with LRS compared with NSS (4.2% in NSS, 26.1% in LRS, P = 0.02). Twenty-four patients (51%) received NSS and 23 patients received LRS. Systemic inflammatory response syndrome (SIRS) at 24 and 48 h, mortality, presence of local complications and inflammatory markers were measured.įorty-seven patients were included. Each group received Normal Saline solution (NSS) or Lactated Ringer's solution (LRS) through a goal-directed fluid resuscitation protocol. The chloride concentration in lactated Ringer’s is similar to that in plasma, and the solution is therefore considered to be balanced. 2 In contrast, another commonly used crystalloid, lactated Ringer’s solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride. The patients were randomized into two groups. Saline (0.9 sodium chloride normal saline) is a commonly used crystalloid, but it has a much higher chloride concentration than human plasma, and is thus unbalanced.
#LACTATED RINGER VS NORMAL SALINE PDF#
Link to Article Link to FULL FREE PDF Modi MP, Vora KS, Parikh GP, Shah VR. lactated ringer’s during renal transplantation. i can explain some other time if anyones interested.) lactated ringers (or ringers lactate) generally has about.
#LACTATED RINGER VS NORMAL SALINE TRIAL#
We performed a randomized controlled trial in patients with acute pancreatitis. Khajavi MR, Etezadi F, Moharari RS, Imani F, Meysamie AP, Khashayar P, Najafi A. normal saline is just nacl in water (although for purposes of serum sodium, it neither adds nor subtracts sodium.
However, there are few studies which focus on types of fluid therapy. Aggressive fluid resuscitation is recommended for initial management of acute pancreatitis.
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